Authors
- Samir PatelCHAROTAR UNIVERSITY OF SCIENCE AND TECHNOLOGY
- Umang ShahCHAROTAR UNIVERSITY OF SCIENCE AND TECHNOLOGYhttp://orcid.org/0000-0001-6748-2137
DOI:
https://doi.org/10.22159/ajpcr.2017.v10i2.15928Abstract
Objective: Flavones occupy a special place in the realm of natural and synthetic organic chemistry owing to their diversified biological activities. In this study, a series of chalcone derivatives were synthesized and after cyclization of chalcone to synthesized various substituted flavone derivatives (2A-2L).Â
2
ÂMethods: The reaction of 2-hydroxy acetophenone with substituted aromatic aldehydes produced chalcone by trituration (NaOH) and conventional methods (KOH/EtOH), which upon further cyclization with dimethyl sulfoxide/I Âresulted to form flavone derivatives.
Results: The purity of compounds was ascertained by melting point and thin-layer chromatography. The synthesized compounds have been characterized by mass, infrared, and1H nuclear magnetic resonance spectral analysis.
Conclusion: Based on spectral data, it was proved that all synthesized chalcones and flavones derivatives meet the standard values of various spectral techniques and further it will be evaluated for pharmacological activities.
Keywords: Chalcone, Flavone, Trituration, Conventional, Claisen-Schmidt condensation.
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Author Biographies
Samir Patel, CHAROTAR UNIVERSITY OF SCIENCE AND TECHNOLOGY
PHARMACEUTICAL CHEMISTRY AND ANALYSIS
Umang Shah, CHAROTAR UNIVERSITY OF SCIENCE AND TECHNOLOGY
PHARMACEUTICAL CHEMISTRY AND ANALYSIS
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Published
01-02-2017
How to Cite
Patel, S., and U. Shah. “SYNTHESIS OF FLAVONES FROM 2-HYDROXY ACETOPHENONE AND AROMATIC ALDEHYDE DERIVATIVES BY CONVENTIONAL METHODS AND GREEN CHEMISTRY APPROACH”. Asian Journal of Pharmaceutical and Clinical Research, vol. 10, no. 2, Feb. 2017, pp. 403-6, doi:10.22159/ajpcr.2017.v10i2.15928.
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Vol 10 Issue 2 February 2017
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